E. Forro and F. Fulop Pages 6178 - 6187 ( 10 )
Kinetic and sequential kinetic enzymatic routes for the synthesis of enantiomeric β - and λ -amino acids through enzymatic ring cleavage of the corresponding lactams in organic solvents or solvent-free systems or a supercritical CO2 medium, and for the enantioselective hydrolysis of the corresponding amino esters in organic solvents are reviewed. In the frame of a practical guide, a simple and rapid GC enantioseparation technique for amino acids, including exact descriptions of selected enzymatic reactions, is additionally presented.
β -amino acid, λ -amino acid, β -amino ester, burkholderia cepacia lipase PS, candida antarctica lipase B, enantiomer, enzymatic catalysis, GC enantioseparation, kinetic resolution, β -lactam, λ -lactam, lipase, organic solvent, sequential resolution, solvent-free system, supercritical CO2.
Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary.