Marina P. Abuçafy, Bruna L. da Silva, João A. Oshiro-Junior, Eloisa B. Manaia, Bruna G. Chiari-Andréo, Renan A. M. Armando, Regina C. G. Frem and Leila A. Chiavacci* Pages 4174 - 4184 ( 11 )
Nanoparticles as drug delivery systems and diagnostic agents have gained much attention in recent years, especially for cancer treatment. Nanocarriers improve the therapeutic efficiency and bioavailability of antitumor drugs, besides providing preferential accumulation at the target site. Among different types of nanocarriers for drug delivery assays, metal-organic frameworks (MOFs) have attracted increasing interest in the academic community. MOFs are an emerging class of coordination polymers constructed of metal nodes or clusters and organic linkers that show the capacity to combine a porous structure with high drug loading through distinct kinds of interactions, overcoming the limitations of traditional drug carriers explored up to date. Despite the rational design and synthesis of MOFs, structural aspects and some applications of these materials like gas adsorption have already been comprehensively described in recent years; it is time to demonstrate their potential applications in biomedicine. In this context, MOFs can be used as drug delivery systems and theranostic platforms due to their ability to release drugs and accommodate imaging agents. This review describes the intrinsic characteristics of nanocarriers used in cancer therapy and highlights the latest advances in MOFs as anticancer drug delivery systems and diagnostic agents.
Metal-organic frameworks, nanocarriers, drug delivery, cancer diagnosis, cancer therapy, cancer theranostics.
Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Highway Araraquara-Jau, Araraquara, SP, Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Highway Araraquara-Jau, Araraquara, SP, Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Highway Araraquara-Jau, Araraquara, SP, Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Highway Araraquara-Jau, Araraquara, SP, Department of Biological and Health Sciences, Universidade de Araraquara, UNIARA, Araraquara, SP, Institute of Chemistry, Department of Inorganic and General Chemistry, Sao Paulo State University-UNESP, SP, Institute of Chemistry, Department of Inorganic and General Chemistry, Sao Paulo State University-UNESP, SP, Sao Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Highway Araraquara-Jau, Araraquara, SP