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Assessment of the Antineoplastic Potential of Chalcones in Animal Models

[ Vol. 20 , Issue. 2 ]

Author(s):

B.I. Roman, T.S.A. Heugebaert, M.E. Bracke and C.V. Stevens   Pages 186 - 221 ( 36 )

Abstract:


One part of chemical space that is endowed with interesting biological properties is the area of the chalcones. With this review, we provide a comprehensive overview of the numerous in vivo animal studies on the antineoplastic potential of both natural and synthetic members of this flavonoid subclass (covering: up to mid-2011). The thus far identified modes of action of these compounds are also discussed. We hope that this overview may stimulate deeper investigations into the biochemical mechanisms by which chalcones exert their antineoplastic action. As a result, in the foreseeable future, chalcones may prove suitable lead molecules or early drug candidates for the prevention or treatment of various neoplastic diseases.

Keywords:

Angiogenesis, animal models, antitumor agents, cancer, cell cycle, chalcones, chemoprevention, cytotoxicity, invasion, in vivo, metastasis, mitosis, natural products, phytochemicals, xenograft experiments

Affiliation:

Research Group SynBioC, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.



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