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General Review Article

The Association between Depression and Gastroesophageal Reflux based on Phylogenetic Analysis of miRNA Biomarkers

[ Vol. 27 , Issue. 38 ]


Yi-Hau Chen and Hsiuying Wang*   Pages 6536 - 6547 ( 12 )


A number of clinical studies have revealed that there is an association between major depression (MD) and gastroesophageal reflux disease (GERD). Both the diseases are shown to affect a large proportion of the global population. More advanced studies for understanding the comorbidity mechanism of these two diseases can shed light on developing new therapies of both diseases. To the best of our knowledge, there has not been any research work in the literature investigating the relationship between MD and GERD using their miRNA biomarkers. We adopt a phylogenetic analysis to analyze their miRNA biomarkers. From our analyzed results, the association between these two diseases can be explored through miRNA phylogeny. In addition to evidence from the phylogenetic analysis, we also demonstrate epidemiological evidence for the relationship between MD and GERD based on Taiwan biobank data.


Major depression, gastroesophageal reflux, microRNA, phylogenetic analysis, MD, GERD, Common digestive disorders.


Institute of Statistical Science, Academia Sinica, Nankang, Taipei, Institute of Statistics, National Chiao Tung University, Hsinchu

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