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Insights into the Effects of Dietary Omega-6/Omega-3 Polyunsaturated Fatty Acid (PUFA) Ratio on Oxidative Metabolic Pathways of Oncological Bone Disease and Global Health

[ Vol. 28 , Issue. 9 ]


Geir Bjørklund*, Maryam Dadar, Monica Daniela Doşa*, Salvatore Chirumbolo and Joeri J. Pen   Pages 1672 - 1682 ( 11 )


Various nutrients have been designated as antioxidants, with a possible effect on diseases like cancer. This is partly due to their effect on prostaglandins, thereby affecting local pathological metabolic acidosis. This paper aims to summarize the culprit pathophysiological mechanisms involved, with a focus on the bone microenvironment. The omega- 6/omega-3 PUFA ratio is particularly investigated for its antioxidative effects, countering these pathways to fight the disease. This feature is looked at concerning its impact on health in general, with a particular focus on malignant bone metastasis.


Antioxidants, Omega-6/omega-3 PUFA ratio, Prostaglandins, Cancer, Bone metastasis, Omega-3 fatty acids, Omega-6 fatty acids.


Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Department of Pharmacology, Faculty of Medicine, Ovidius University, Constanta, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Diabetes Clinic, Department of Internal Medicine, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels

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