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Survey of Recent Literature Related to the Biologically Active 4(3H)-Quinazolinones Containing Fused Heterocycles

[ Vol. 20 , Issue. 6 ]

Author(s):

Martine Demeunynck and Isabelle Baussanne   Pages 794 - 814 ( 21 )

Abstract:


the present review focuses on the synthesis and biological evaluation of polycyclic 4(3H)-quinazolinones containing fused aromatic or heteroaromatic rings. The first part of the review is related to compounds with ring fused to the pyrimidine part of the quinazoline core. Most of the quinazolinone alkaloids belong to this class of molecules. The second part presents molecules bearing extra ring(s) fused to the benzo moiety of the quinazolinone skeleton. Their structural diversity opens new fields in the search of active molecules.

Keywords:

Quinazoline, quinazolinone, nitrogen heterocycles, antitumor agents, antiviral

Affiliation:

Departement de Pharmacochimie Moleculaire, UMR 5063 CNRS/Universite Joseph Fourier, BP 53, 38041 Grenoble cedex 9, France.



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