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Flavonoids in Atherosclerosis: An Overview of Their Mechanisms of Action

[ Vol. 20 , Issue. 21 ]


G. Siasos, D. Tousoulis, V. Tsigkou, E. Kokkou, E. Oikonomou, M. Vavuranakis, E.K. Basdra, A.G. Papavassiliou and C. Stefanadis   Pages 2641 - 2660 ( 20 )


Polyphenols are composed of a wide variety of molecules that are classified into several categories, according to their chemical type such as phenolic acids, flavonoids, stilbenes, and lignans. Many studies have proven the beneficial effects of flavonoids in atherosclerosis progression and cardiovascular disease. Dietary flavonoids reduce oxidative stress and exert anti-inflammatory actions. Moreover, flavonoids have the ability to avoid the thrombus formation, improve endothelial function, modify lipid levels and regulate glucose metabolism. In the context of this evidence in this review article we summarize the so far acquired knowledge of the most important mechanisms of action of flavonoids in atherosclerosis progression.


Antioxidants, atheroscierosis, cardiovascular disease, flavonoids, inflammation.


University of Athens Medical School, Mikras Asias 75, Athens, Greece.

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