Li Jiajing, Ekaterina V. Kochurova, Narasimha M Beeraka, Natalya V. Lapina, Chang Weilong, Dmitrii M. Belousov, Elizaveta V. Mikhaylenko, Vladimir N. Nikolenko, Cristian Muresanu, Siva G. Somasundaram, Cecil E. Kirkland*, Marco Avila-Rodríguez and Gjumrakch Aliev Pages 3413 - 3421 ( 9 )
Background: A patient was evaluated with respect to the effects and results of a complex treatment plan for complete dental rehabilitation. Several steps were required. Each step included immunological tests of salivary biomarkers. Clinical and immunological assessments were evaluated on Day 3, Week 2, Month 3, and Month 6 post-surgery. These evaluations guided the decision-making process with regard to preparation of a permanent prosthesis.
Objective: The aim of the study is to evaluate the response of tissues and organs of the maxillofacial region in patients during dental rehabilitation after maxillofacial surgery.
Methods: Complex treatment and rehabilitation involving cooperation between the specialists in maxillofacial surgery, prosthetic dentistry, and cancer immunology.
Results: Long-term monitoring and clinical examination showed a direct relationship between the patient’s clinical and dental status and the changes in oral fluid biomarkers.
Conclusion: The data revealed that the oral fluid biomarkers reflected the patient’s adaptation to prosthodontic rehabilitation. Treatment and monitoring of a maxillofacial tumor patient could use biomarkers as a non-invasive indicator.
Prosthodontic rehabilitation, oral and maxillofacial region, tumor, saliva, biomarker, prosthetic rehabilitation.
Department of Pathology, The First Affiliated Hospital of Zhengzhou University, No.1, Jianshe Road, Zhengzhou, 450052, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya str., Moscow, 119991, Center of Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysore - 570 015, Karnataka, Federal State Budgetary Institution of Higher Professional Education “Kuban State Medical University” of the Ministry of Healthcare of the Russian Federation (KubSMU MOH Russia), Street M. Sedina, Krasnodar, 350063, Department of General Surgery, The First Affiliated Hospital of Zhengzhou University, No.1, Jianshe Road, Zhengzhou, 450052, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya str., Moscow, 119991, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya str., Moscow, 119991, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya str., Moscow, 119991, Research Center for Applied Biotechnology in Diagnosis and Molecular Therapies (BIODIATECH), Str. Trifoiului nr. 12 G, 400478, Cluj-Napoca, Department of Biological Sciences, Salem University, 223 West Main Street Salem, WV 26426, Department of Biological Sciences, Salem University, 223 West Main Street Salem, WV 26426, Department of Clinical Sciences, Faculty of Health Sciences, University of Tolima, Ibagué 730001, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya str., Moscow, 119991