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The Main Receptors Involved in the COVID-19: A Systematic Review and Meta-Analysis

[ Vol. 28 , Issue. 34 ]


Alice Barros Câmara* and Igor Augusto Brandão   Pages 7157 - 7184 ( 28 )


Objective: This review aims to study the receptor's family and functions most related to COVID-19 infection and also suggest the tissue and cell location on which the majority of COVID-19 receptors are mainly expressed.

Methods: This systematic review is according to PRISMA guidelines. PubMed, Cochrane, SciELO, Lilacs, Web of Science, and DOAJ databases were used. Clinical trials and research articles studying receptors related to COVID-19 were included in this review. R programming language was used to elaborate charts and receptors network, and SPSS(26v) software was used to perform statistical analysis (PROSPERO: CRD42020210643).

Results: The majority of studies on the involvement of receptors in COVID-19 included plasma receptors and G protein-coupled receptor families (p<0.05). These receptors are highly expressed in the brain (24%) and 80% of them can interact with each other in a protein network, exerting some regulatory effects on various tissues. The main influential receptor in the network of receptors involved in the COVID-19 was the EGFR and the majority of receptors were associated with pathological processes of the disease (p<0.05), including the amplification of inflammatory responses in COVID-19, which may be related to neurological disorders in some cases. Studies on receptors involved in the COVID-19 included mainly patients from the United States, Spain, and Brazil (p<0.05).

Conclusion: Plasma receptors and G protein-coupled receptors, especially the EGFR, involved in pathological effects of the COVID-19 inflammatory process in the brain have shown significant importance in this review.


Brain, COVID-19, epidermal growth factor receptor, G protein-coupled receptor, inflammation, plasmareceptors.


Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal

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