Marthandam Asokan Shibu, Mahalakshmi Bharath and Bharath Kumar Velmurugan* Pages 6895 - 6914 ( 20 )
Ferroptosis plays a critical regulatory role as a new kind of cell death, initiating and developing an array of disorders like neurological diseases, acute injury of kidney, tumors, and ischemia, etc. Although selective deposition of iron is one of the pathogenic reasons for PD, it’s underlying mechanism is still unknown. In this review, the role of neuroinflammation in Parkinson’s disease (PD) leading to neurodegeneration has been discussed in detail. The accumulation of brain iron has been found in many chronic neurological disorders, including PD. We have also discussed the unique features of ferroptosis , and it links in aggravating the pathology of PD. Further, the concept of targeting ferroptosis for PD pathology and inducers and inhibitors, pharmacological drugs and clinical trials for PD candidates in phase IV stage in completed status are detailed in the respective sections.
Ferroptosis, Parkinson's disease, iron accumulation, inflammation, neurodegeneration, drugs.
Cardiovascular and Mitochondria Related Diseases Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Department of Research and Development, Vels Publisher, Bodinayakanur, Tamil Nadu, Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung