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General Review Article

Potential Benefits of Phytochemicals for Abdominal Aortic Aneurysm

[ Vol. 28 , Issue. 41 ]


Azar Hosseini, Peter E. Penson, Arrigo F.G. Cicero, Jonathan Golledge, Khalid Al-Rasadi, Tannaz Jamialahmadi and Amirhossein Sahebkar*   Pages 8595 - 8607 ( 13 )


Background: Abdominal aortic aneurysms (AAAs) are a leading cause of death in older adults due to aortic rupture. There are currently no effective medical therapies for AAA, with surgery being the only acceptable treatment. There is frequently an extended period between AAA diagnosis and treatment by corrective surgery, during which an effective drug therapy could prevent or delay the need for AAA repair. Objective: This review aimed to critically summarize prior research investigating the potential benefits of phytochemicals in preventing or treating AAA.

Methods: In vitro, in vivo, and human studies examining the effect of phytochemicals in AAA models and patients were critically summarised.

Results: Some preliminary data support the further investigation of curcumin, radix astragali, grape seed polyphenols, resveratrol, Ginkgo biloba extract (EGb 761), Ginsenoide Rb1, Dan Hong, Epigallocatechin-3-gallate, Baicalein, Fucoidan, Quercetin, and Salvianolic acid as potential treatments for AAA.

Conclusion: Experimental in vivo and in vitro studies suggest the potential benefits of a number of medicinal herbs and phytochemicals in preventing or reducing the progression of AAA. In order to assess whether these findings can be translated into proven treatments, adequately designed double-blind randomized clinical trials will be required.


Abdominal aortic aneurysm, oxidative stress, phytotherapy, inflammation, plant medicine, phytochemicals.


Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, Atherosclerosis Research Unit, Medical and Surgical Sciences Department, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Queensland, Department of Clinical Biochemistry, Sultan Qaboos University Hospital, Muscat, Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad

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