Ali Ehsani, Asma Jodaei, Mohammad Barzegar-Jalali, Ezzatollah Fathi, Raheleh Farahzadi* and Khosro Adibkia* Pages 1804 - 1823 ( 20 )
Nanoparticles (NPs), due to their medical applications, are widely used. Accordingly, the use of mesenchymal stem cells is one of the most important alternatives in the tissue engineering field. NPs play effective roles in stem cells proliferation and differentiation. The combination of NPs and tissue regeneration by stem cells has created a new therapeutic approach towards humanity. Of note, the physicochemical properties of NPs determine their biological function. Interestingly, various mechanisms such as modulation of signaling pathways and generation of reactive oxygen species, are involved in NPs-induced cellular proliferation and differentiation. This review summarized the types of nanomaterials effective on stem cell differentiation, the physicochemical features, biomedical application of these materials and the relationship between nanomaterials and environment.
Nanoparticles, Mesenchymal stem cells, Tissue regeneration, Cell differentiation, Biomedical application, Nanomaterials.
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, , Department of Pharmaceutical Sciences, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, , Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, , Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, , Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, , Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz