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New Molecular Strategies for Reducing Implantable Medical Devices Associated Infections

[ Vol. 21 , Issue. 29 ]

Author(s):

Alina Maria Holban, Monica Cartelle Gestal and Alexandru Mihai Grumezescu   Pages 3375 - 3382 ( 8 )

Abstract:


Due to the great prevalence of persistent and recurrent implanted device associated-infections novel and alternative therapeutic approaches are intensely investigated. For reducing complications and antibiotic resistance development, one major strategy is using natural or synthetic modulators for targeting microbial molecular pathways which are not related with cell multiplication and death, as Quorum Sensing, virulence and biofilm formation. The purpose of this review paper is to discuss the most recent in vitro approaches, investigating the efficiency of some novel antimicrobial products and the nano-technologic progress performed in order to increase their effect and stability.

Keywords:

Controlled release, implant-associated infections, nano-carriers, natural modulators, synthetic modulators, virulence.

Affiliation:

Faculty of Applied Chemistry and Materials Science, “Politehnica” University of Bucharest, Department of Science and Engineering of Oxide Materials and Nanomaterials, 1–7 Polizu Street, 011061 Bucharest, Romania.



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