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Review Article

Modern Drug Design and Lead Discovery: An Overview

[ Vol. 3 , Issue. 5 ]


E.L. Setti and R. Micetich   Pages 317 - 324 ( 8 )


The design of novel therapeutic agents to treat specific diseases has always been the aim of the medicinal chemist. Today, using the three­ dimensional structure of the target-ligand complex as the main tool, it is possible to design novel therapeutic compounds with a specific mode of action. Knowledge of the molecular basis of the disease, the structure of the biological target (enzyme or receptor) and the mechanism of drug action are essential to succeed in this challenging task.

In addition, the recent explosion of combinatorial chemistry techniques, along with the development of high throughput and automated techniques that permit screening of thousands of compounds per month against a given target, offer an unparallel opportunity for medicinal chemists to increase significantly the prospect of finding new bioactive molecules, in a relatively short period of time.



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