Phillip M. Cowley* and David C. Rees Pages 211 - 227 ( 17 )
This review aims to highlight the opportunities for the utilisation of solid-phase synthesis in the process of drug discovery. The two main sections discuss the preparation and biological testing of compound libraries and the preparation of compound arrays based around approved drugs. Biologically active compounds in assays for enzyme inhibition, membrane bound protein ligands and intracellular hormone receptors are discussed, illustrating the power of this relatively new tool in the arena of medicinal chemistry.