Shijun Ren, Linda L. Lien and Eric J. Lien* Pages 271 - 278 ( 8 )
Twenty benzamide derivatives with and without EPS side effects have been compared in terms of their physicochemical properties and 3-D molecular modeling using the HyperChem program and the CQSAR program. While no single determining physicochemical property can be identified with the EPS side effects. Similarities and differences of the 3-D structures do exist among the ones with and without EPS side effects. These 3-D models of the ones without EPS side effects may be used tor further development of each subclass of therapeutic agents with improved pharmacological profile.