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Review Article

Dihydrochalcones as Antitumor Agents

[ Vol. 29 , Issue. 30 ]


Fabiola De Luca, Carla Di Chio, Maria Zappalà and Roberta Ettari*   Pages 5042 - 5061 ( 20 )


Dihydrochalcones are a class of secondary metabolites, possessing several biological properties such as antitumor, antioxidant, antibacterial, antidiabetic, estrogenic, anti-inflammatory, antithrombotic, antiviral, neuroprotective, and immunomodulatory properties; therefore, they are currently considered promising candidates in the drug discovery process. This review intends to debate their pharmacological actions with particular attention to their antitumor activity against a panel of cancer cell lines and to the description of the inhibition mechanisms of cell proliferation such as the regulation of angiogenesis, apoptosis, etc.


Chalcones, dihydrochalcones, antitumor agents, cell lines, antioxidant, antibacterial.


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