Santanu Bhattacharya and Padmaparna Chaudhuri Pages 1762 - 1777 ( 16 )
Properties of benzimidazole and its derivatives have been studied for over hundred years; special interest of researchers triggered by the fact that 5,6-dimethylbenzimidazole is a component of naturally occurring vitamin B12. Several antihelminthic, antacid and antibacterial drugs are known which have benzimidazole moiety as their essential constituent. Additionally, several bis- and trisbenzimidazole based systems are well-known for their interaction with DNA and interference with several DNA associated processes. This account gives an overview of the benzimidazole based systems and their relevance in medicinal chemistry.
Antibacterial,DNA-alkylation,intercalation,major- and minor-groove,transcription factor,polymerase,helicase,topoisomerase
, Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India.