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General Review Article

Putative Therapeutic Impact of Inflammasome Inhibitors against COVID-19-Induced ARDS

[ Vol. 30 , Issue. 12 ]


Seyed Fazel Nabavi, Adeleh Sahebnasagh, Ahad Shahbazi, Seyed Mohammad Nabavi*, Saeid Azimi, Malihe Khayat Kashani, Solomon Habtemariam, Mojde Rahmani, Mohadese Badiee, Javad Hashemi, Fatemeh Saghafi, Kiumarth Amini, Mina Azimi and Aysa Rezabakhsh*   Pages 1406 - 1419 ( 14 )


Given the importance of COVID-19-induced ARDS, recently, researchers have strived to determine underlying mechanisms involved in the inflammatory responses. In this regard, inflammasomes possess a distinct priority for cytokine storm occurrence and, subsequently, ARDS progression in ill patients with SARS-CoV-2 infection. In this minireview, the characteristics of known inflammasome inhibitors and designed research in this field were concretely deciphered.


ARDS, COVID-19, inflammasome, inhibitors, NLRP3, SARS-CoV-2.


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