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Review Article

CD155-TIGIT Axis as a Therapeutic Target for Cancer Immunotherapy

[ Vol. 31 , Issue. 13 ]


Yeteng Mu and Xingang Guan*   Pages 1634 - 1645 ( 12 )


Immune checkpoint inhibitors (ICIs) have shown unprecedented efficacy in treating many advanced cancers. Although FDA-approved ICIs have shown promising efficacy in treating many advanced cancers, their application is greatly limited by the low response rate, immune-related adverse events (irAE), and drug resistance. Developing novel ICIs holds great promise to improve the survival and prognosis of advanced cancer patients. T-Cell immunoglobulin and ITIM domain (TIGIT) is an inhibitory receptor expressed on T cells, natural killer (NK) cells, and T regulatory cells. Increasing reports have shown that the disrupting CD155-TIGIT axis could activate the immune system and restore antitumor immune response. This review briefly summarized the role of TIGIT in tumor immune escape and targeting CD155-TIGIT axis drugs in preclinical and clinical trials for cancer immunotherapy.


TIGIT, CD155, PD-1, immune checkpoint inhibitor, cancer immunotherapy, tumor cells.


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