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Hydrogen Sulfide: Physiological Roles and Therapeutic Implications against COVID-19


Sajad Abolfazli, Nima Ebrahimi, Eftekhar Morabi, Mohammad Amin Asgari Yazdi, Gokhan Zengin, Thozhukat Sathyapalan, Tannaz Jamialahmadi and Amirhossein Sahebkar*   Pages 1 - 17 ( 17 )


The COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) poses a major menace to economic and public health worldwide. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are two host proteins that play an essential function in the entry of SARS-- COV-2 into host cells. Hydrogen sulfide (H2S), a new gasotransmitter, has been shown to protect the lungs from potential damage through its anti-inflammatory, antioxidant, antiviral, and anti-aging effects. It is well known that H2S is crucial in controlling the inflammatory reaction and the pro-inflammatory cytokine storm. Therefore, it has been suggested that some H2S donors may help treat acute lung inflammation. Furthermore, recent research illuminates a number of mechanisms of action that may explain the antiviral properties of H2S. Some early clinical findings indicate a negative correlation between endogenous H2S concentrations and COVID-19 intensity. Therefore, reusing H2S-releasing drugs could represent a curative option for COVID-19 therapy.


Hydrogen sulfide, cytokine storm, anti-inflammatory, anti-viral, COVID-19, coronavirus.


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