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Review Article

The Function of Autophagy in the Initiation, and Development of Breast Cancer

[ Vol. 31 , Issue. 20 ]


Elmira Aboutalebi Vand Beilankouhi, Mohammad Valilo, Narges Dastmalchi, Shahram Teimourian and Reza Safaralizadeh*   Pages 2974 - 2990 ( 17 )


Autophagy is a significant catabolic procedure that increases in stressful conditions. This mechanism is mostly triggered after damage to the organelles, the presence of unnatural proteins, and nutrient recycling in reaction to these stresses. One of the key points in this article is that cleaning and preserving damaged organelles and accumulated molecules through autophagy in normal cells helps prevent cancer. Since dysfunction of autophagy is associated with various diseases, including cancer, it has a dual function in tumor suppression and expansion. It has newly become clear that the regulation of autophagy can be used for the treatment of breast cancer, which has a promising effect of increasing the efficiency of anticancer treatment in a tissue- and cell-type-specific manner by affecting the fundamental molecular mechanisms. Regulation of autophagy and its function in tumorigenesis is a vital part of modern anticancer techniques. This study discusses the current advances related to the mechanisms that describe essential modulators of autophagy involved in the metastasis of cancers and the development of new breast cancer treatments.


Autophagy, breast cancer, metastasis, cancer therapy, anticancer techniques, damaged.


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