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Structure Diversity, Synthesis, and Biological Activity of Cyathane Diterpenoids in Higher Fungi

[ Vol. 22 , Issue. 19 ]

Author(s):

Hao-Yu Tang, Xia Yin, Cheng-Chen Zhang, Qian Jia and Jin-Ming Gao   Pages 2375 - 2391 ( 17 )

Abstract:


Cyathane diterpenoids, occurring exclusively in higher basidiomycete (mushrooms), represent a structurally diverse class of natural products based on a characteristic 5-6-7 tricyclic carbon scaffold, including 105 members reported to date. These compounds show a diverse range of biological activities, such as antimicrobial, anti-MRSA, agonistic toward the kappa-opioid receptor, antiinflammatory, anti-proliferative and nerve growth factor (NGF)-like properties. The present review focuses on the structure diversity, structure elucidation and biological studies of these compounds, including mechanisms of actions and structure-activity relationships (SARs). In addition, new progress in chemical synthesis of cyathane diterpenoids is discussed.

Keywords:

Basidiomycete, cyathane diterpenes, enantioselective synthesis, mushroom, natural products, NGF synthesis inducers, structure-activity relationships.

Affiliation:

Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, P.R. China.



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