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Review Article

Anti-gout and urate-lowering potentials of curcumin: A review from bench to beside


Amir Masoud Jafari-Nozad, Amirsajad Jafari, Saman Yousefi, Hasan Bakhshi, Tahereh Farkhondeh and Saeed Samarghandian*   Pages 1 - 18 ( 18 )


Background: Gouty arthritis is a complex form of inflammatory arthritis, triggered by the sedimentation of monosodium urate crystals in periarticular tissues, synovial joints, and other sites in the body. Curcumin is a natural polyphenol compound, isolated from the rhizome of the plant Curcuma longa, possessing countless physiological features, including antioxidant, anti-inflammatory, and anti-rheumatic qualities.

Objective: This study aimed to discuss the beneficial impacts of curcumin and its mechanism in treating gout disease.

Methods: Ten English and Persian databases were used to conduct a thorough literature search. Studies examining the anti-gouty arthritis effects of curcumin and meeting the inclusion criteria were included.

Results: According to the studies, curcumin has shown xanthine oxidase and urate transporter- 1 inhibitory properties, uric acid inhibitory characteristics, and antioxidant and anti- inflammatory effects. However, some articles found no prominent reduction in uric acid levels.

Conclusion: In this review, we emphasized the potency of curcumin and its compounds against gouty arthritis. Despite the potency, we suggest an additional well-designed evaluation of curcumin, before its therapeutic effectiveness is completely approved as an anti-- gouty arthritis agent.


Arthritis, joint diseases, curcumin, gout, uric acid, curcuma longa.


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