Shu-Fang Li, Wei Zhang, Wen Zhang, An Huang, Jia-Qi Zhu, Ya-Jun Wang* and Yu-Guo Zheng Pages 1 - 21 ( 21 )
Atorvastatin, a lipid-lowering drug that is widely used in the treatment of cardiovascular diseases, has significant clinical significance. This article focuses on the synthetic procedures of atorvastatin, including Paal-Knorr synthesis and several new synthetic strategies. It also outlines chemical and chemo-enzymatic methods for synthesizing optically active side chain of atorvastatin. In addition, a comprehensive overview of the analytical monitoring techniques for atorvastatin and its metabolites and impurities is reported, alongside a discussion of their strengths and limitations.
Atorvastatin,synthetic route,Paal-Knorr synthesis,side chain,tert-butyl (3R,5R)-dihydroxyheptanoate,impurity