DNA Repair in Normal and Cancer Stem Cells, with Special Reference to the Central Nervous System

Author(s):

Guido Frosina   Pages 854 - 866 ( 13 )

Abstract:

Stem cells build and maintain organisms. Accordingly, they are particularly well-protected from damage to DNA and other cellular components. This feature becomes a serious drawback when stem cells transform and develop cancer, because they resist to radiation and chemotherapy. Various mechanisms ensure protection of stem cells. In normal stem cells enhanced DNA repair is often one of them. Whether the same holds for cancer stem cells still is an open question.

Keywords:

Stem cells,differentiation,DNA repair,CD133,cancer

Affiliation:

Molecular Mutagenesis&DNA Repair Unit, Istituto Nazionale Ricerca Cancro, Largo Rosanna Benzi n. 10, 16132 Genova, Italy.

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