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Review Article

Iron-related Biomarkers in the Diagnosis and Management of Iron Disorders


Yuliya Semenova, Geir Bjørklund*, Monica Butnariu and Massimiliano Peana   Pages 1 - 16 ( 16 )


Background: Iron deficiency and iron-related disorders are common health issues worldwide, affecting a significant proportion of the population. Diagnosis and management of these disorders rely heavily on using various iron-related biomarkers that can provide valuable clinical information.

Objective: This review article provides an overview of the most commonly used iron-related biomarkers, including serum ferritin, transferrin saturation, soluble transferrin receptor, zinc protoporphyrin, and free erythrocyte protoporphyrin. Other emerging biomarkers, such as hepcidin and retinol-binding protein 4, are also discussed.

Results: Iron plays a vital role in various physiological processes, including oxygen transport, energy metabolism, and DNA synthesis. The article highlights the advantages and limitations of iron biomarkers and their clinical applications in diagnosing and managing iron deficiency and iron-related anemia.

Conclusion: Using iron-related biomarkers in screening and monitoring programs can improve patient outcomes and reduce healthcare costs.


Iron, iron deficiency, iron-related disorders, biomarkers, hepcidin, serum ferritin.


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