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Vitamin D and the Epigenetic Machinery in Colon Cancer

[ Vol. 24 , Issue. 9 ]

Author(s):

Meiyan Sun* and Bin Guo*   Pages 888 - 897 ( 10 )

Abstract:


Vitamin D is an important hormone that regulates many physiological processes related to human health. Through its nuclear receptor, VDR, vitamin D controls gene expression through genetic and epigenetic mechanisms. Increasing data have demonstrated the anti-cancer activities of vitamin D in various cancers, including colon cancer. This review summarizes the recent progresses in our understanding of the molecular mechanisms of vitamin D and its interaction with the epigenetic machinery in colon cancer. Vitamin D changes the status of DNA methylation and histone modifications, resulting in the activation of tumor suppressors and inhibition of oncogenes. In addition, vitamin D activates the expression of tumor suppressing miRNAs, which contribute to the tumor suppressive activity. Further understanding of the epigenetic action of vitamin D will help the development of therapeutic strategies targeting the vitamin D signaling pathway without inducing the hypercalcemic side effects.

Keywords:

Vitamin D, epigenetics, microRNA, DNA methylation, histone methylation, chemotherapy.

Affiliation:

Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77030, Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77030



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