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Structure-activity Relationship Studies of New Marine Anticancer Agents and their Synthetic Analogues

[ Vol. 24 , Issue. 42 ]

Author(s):

Sergey N. Fedorov*, Valentin A. Stonik, Friedemann Honecker and Sergey A. Dyshlovoy   Pages 4779 - 4799 ( 21 )

Abstract:


This review addresses in-depth recent structure-activity relationship (SAR) studies published in 2015 on new marine compounds and their synthetic analogues with potential or established anticancer activity. Priority was given to papers on in vitro screening methods of marine-derived bioactive compounds, usually performed using panels of human cancer cell lines, as a first step of the anticancer drugs discovery process. Our review describes compounds belonging to different classes of substances, namely terpenoids, glycosides, alkaloids, steroids, as well as other small molecular compounds. We believe that our review will not only help chemists in the design and synthesis of novel anticancer compounds possessing specific cytotoxic or cytostatic activity in human cancer cells, but will also extend the existing databases comprising data on bioactivity of marine natural compounds.

Keywords:

Marine natural compounds, anticancer activity, structure-activity relationship (SAR) study, alkaloids, glycosides, terpenoids, steroids.

Affiliation:

Laboratory of Marine Natural Products Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East Branch, Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Laboratory of Marine Natural Products Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East Branch, Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022, Tumor and Breast Center ZeTuP St. Gallen, Rorschacher Strasse 150, St. Gallen 9006, Laboratory of Marine Natural Products Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East Branch, Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022



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