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Chemical and Biological Aspects of the Natural 1,4-Benzoquinone Embelin and its (semi-)Synthetic Derivatives

[ Vol. 24 , Issue. 18 ]

Author(s):

Priti Singh Shuveksh, Khursheed Ahmed, Subhash Padhye, Rainer Schobert and Bernhard Biersack   Pages 1998 - 2009 ( 12 )

Abstract:


Background: Like the impressive biological properties of embelin, its chemical aspects have raised the interest of scientists in the field as well. A detailed understanding of the chemistry of embelin is necessary to fully exploit it medicinally.

Methods: Search for embelin isolation and its chemical modifications was carried out using web-based literature searching tools such as Pubmed and Scifinder. Pertinent literature is covered up to 2016. Structures of bioactive embelin derivatives are provided.

Results: Pure embelin, obtained from Embelia ribes berries extraction or by total synthesis, was applied for a number of biological assays. Semi-synthetic and total synthetic approaches led to new high affinity embelin-derived inhibitors of crucial protein targets and to new embelin derivatives with improved pharmacological properties (e.g., with better water-solubility or as applications for drug carrier systems).

Conclusion: This review provides a summary of the rich chemistry of embelin and the latest developments in the field of optimized (semi-)synthetic embelin derivatives including their biological activities.

Keywords:

Embelin, natural products, benzoquinone, antioxidant, drug design, (semi-)synthetic embelin derivatives.

Affiliation:

ISTRA, Abeda Inamdar Senior College, University of Pune, Pune 411001, ISTRA, Abeda Inamdar Senior College, University of Pune, Pune 411001, ISTRA, Abeda Inamdar Senior College, University of Pune, Pune 411001, Organic Chemistry Laboratory, Faculty of Biology, Chemistry, and Earth Sciences, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Organic Chemistry Laboratory, Faculty of Biology, Chemistry, and Earth Sciences, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth



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