Sauri Hernandez-Resendiz, Kroekkiat Chinda, Sang-Bing Ong, Hector Cabrera-Fuentes, Cecilia Zazueta and Derek j. Hausenloy* Pages 1275 - 1293 ( 19 )
Background: The inflammatory response to acute myocardial ischaemia/ reperfusion injury (IRI) plays a critical role in determining myocardial infarct (MI) size, and subsequent post-MI left ventricular (LV) remodelling, making it a potential therapeutic target for improving clinical outcomes in patients presenting with an acute myocardial infarction (AMI). Recent experimental studies using advanced imaging and molecular techniques, have yielded new insights into the mechanisms through which reactive oxygen species (ROS) contribute to the inflammatory response induced by acute myocardial IRI - “adding fuel to the fire”. The infiltration of inflammatory cells into the MI zone, leads to elevated myocardial concentrations of ROS, cytokine release, and activation of apoptotic and necrotic death pathways. Anti-oxidant and anti-inflammatory therapies have failed to protect the heart against acute myocardial IRI. This may be, in part, due to a lack of understanding of the time course, nature and mechanisms of the inflammation and redox dysregulation, which occur in the setting of acute myocardial IRI.
Conclusion: In this article, we examine the inflammatory response and redox dysregulation induced by acute myocardial IRI, and highlight potential therapeutic options for targeting redox dysregulation, in order to attenuate the detrimental effects of the inflammatory response following an AMI, so as to reduce MI size and prevent heart failure.
Myocardial ischaemia/reperfusion injury, redox dysregulation, inflammation, reactive oxygen species, oxidative stress, neutrophils.
National Heart Research Institute Singapore, National Heart Centre Singapore, Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok, National Heart Research Institute Singapore, National Heart Centre Singapore, National Heart Research Institute Singapore, National Heart Centre Singapore, Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Mexico, Mexico City, National Heart Research Institute Singapore, National Heart Centre Singapore