Systemic Sclerosis at the Cellular Level: Molecular Pathways of Pathogenesis and its Implication on Future Drug Design

Author(s):

S. W. Schulz and C. T. Derk   Pages 3986 - 3995 ( 10 )

Abstract:

Endothelial cell abnormalities and the effects on the surrounding microvasculature is a focal point in the pathogenesis of Systemic Sclerosis disease and may even be the sentinel event for the initiation of this disorder. A better understanding of these processes may improve our understanding of the pathophysiology of Systemic Sclerosis and more specifically the vasculopathy observed. Such knowledge will help us to further current treatments options and design novel therapies for Systemic Sclerosis and other fibrotic disorders.

Keywords:

Scleroderma,systemic sclerosis,fibrosis,vasculopathy,Raynaud's,pathogenesis

Affiliation:

, Division of Rheumatology, Thomas Jefferson University, 613 Curtis Bldg, 1015 Walnut Street, Philadelphia, PA 19107, USA.

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