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Targeting DNA Minor Groove by Hybrid Molecules as Anticancer Agents

[ Vol. 24 , Issue. 26 ]

Author(s):

Shalini Nekkanti , Ramya Tokala and Nagula Shankaraiah *   Pages 2887 - 2907 ( 21 )

Abstract:


Agents which can recognize and bind specific sequences of DNA offer selective therapy through the modulation of specific transcription factors or genes. Recently, there has been renewed interest in the field of anticancer minor groove binders. This may be attributed to the fact that many compounds of this class have demonstrated significant antitumor activity against a wide variety of cancers in recent clinical trials. This review will discuss the recent efforts to overcome the drawbacks of existing minor groove binding anticancer agents through rational drug design based on scaffolds with known antitumor activity.

Keywords:

Anticancer, distamycin derivatives, DNA minor groove, pyrrolo[2, 1-c][1, 4]benzodiazepines, small molecules, β-carboline.

Affiliation:

Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037



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