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Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids

[ Vol. 25 , Issue. 3 ]


Paramjit S. Tappia*, Adriana Adameova and Naranjan S. Dhalla   Pages 336 - 345 ( 10 )


Background: Patients with diabetes mellitus have an increased risk of mortality due to cardiovascular complications. Supplementation with specific sulphur-containing amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes and associated cardiovascular complications.

Observations: It is well-known that oxidative stress plays an important role in the pathogenesis of diabetes-induced cardiovascular disease, which is invariably associated with abnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome. Cysteine and taurine are among the most common sulphur-containing amino acids and their cellular levels decline during diabetes that may contribute to the development of the cardiomyopathy. Although sulphur-containing agents exert multiple actions on cellular and subcellular functions in the heart, they also exhibit antioxidant properties and thus may exert beneficial effects in different pathophysiological conditions.

Conclusion: It is concluded that reduction of oxidative stress by cysteine and taurine may serve as an important mechanism for the attenuation of diabetes-induced subcellular and functional abnormalities in the heart.


Sulphur-containing amino acids, Taurine, Cysteine, Diabetes mellitus, Diabetic cardiomyopathy, Preventive nutrition.


Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Department of Physiology & Pathophysiology, Institute of Cardiovascular Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg

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