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Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids

[ Vol. 25 , Issue. 3 ]

Author(s):

Paramjit S. Tappia*, Adriana Adameova and Naranjan S. Dhalla   Pages 336 - 345 ( 10 )

Abstract:


Background: Patients with diabetes mellitus have an increased risk of mortality due to cardiovascular complications. Supplementation with specific sulphur-containing amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes and associated cardiovascular complications.

Observations: It is well-known that oxidative stress plays an important role in the pathogenesis of diabetes-induced cardiovascular disease, which is invariably associated with abnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome. Cysteine and taurine are among the most common sulphur-containing amino acids and their cellular levels decline during diabetes that may contribute to the development of the cardiomyopathy. Although sulphur-containing agents exert multiple actions on cellular and subcellular functions in the heart, they also exhibit antioxidant properties and thus may exert beneficial effects in different pathophysiological conditions.

Conclusion: It is concluded that reduction of oxidative stress by cysteine and taurine may serve as an important mechanism for the attenuation of diabetes-induced subcellular and functional abnormalities in the heart.

Keywords:

Sulphur-containing amino acids, Taurine, Cysteine, Diabetes mellitus, Diabetic cardiomyopathy, Preventive nutrition.

Affiliation:

Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Department of Physiology & Pathophysiology, Institute of Cardiovascular Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg



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