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Sarcopenia, Aging and Prospective Interventional Strategies

[ Vol. 25 , Issue. 40 ]

Author(s):

Tyler B. Waltz, Elayne M. Fivenson , Marya Morevati , Chuanhao Li , Kevin G. Becker , Vilhelm A. Bohr and Evandro Fei Fang*   Pages 5588 - 5595 ( 8 )

Abstract:


Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.

Keywords:

Sarcopenia, aging, mitochondria, mitophagy, phytochemical, nicotinamide adenine dinucleotide.

Affiliation:

Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health Baltimore, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health Baltimore, Department of Chemical and Environmental Engineering, Yale University, New Haven, Connecticut 06520-8276, Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, Laboratory of Molecular Gerontology, National Institute on Aging, NIH



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