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Nutraceuticals and "Repurposed" Drugs of Phytochemical Origin in Prevention and Interception of Chronic Degenerative Diseases and Cancer

[ Vol. 26 , Issue. 6 ]

Author(s):

Adriana Albini, Barbara Bassani, Denisa Baci, Katiuscia Dallaglio, Matteo Gallazzi, Paola Corradino, Antonino Bruno and Douglas M. Noonan*   Pages 973 - 987 ( 15 )

Abstract:


Background: Chronic, degenerative diseases are often characterized by inflammation and aberrant angiogenesis. For these pathologies, including rheumatoid arthritis, cardiovascular and autoimmune diseases, cancer, diabetes, and obesity, current therapies have limited efficacy.

Objectives: The validation of novel (chemo)preventive and interceptive approaches, and the use of new or repurposed agents, alone or in combination with registered drugs, are urgently required.

Results: Phytochemicals (triterpenoids, flavonoids, retinoids) and their derivatives, nonsteroidal anti-inflammatory drugs (aspirin) as well as biguanides (metformin and phenformin) originally developed from phytochemical backbones, are multi-target agents showing antiangiogenic and anti-anti-inflammatory proprieties. Many of them target AMPK and metabolic pathways such as the mTOR axis. We summarize the beneficial effects of several compounds in conferring protection and supporting therapy, and as a paradigm, we present data on terpenoids & biquanides on beer hop xanthohumol and hydroxytryrosol from olive mill waste waters.

Conclusions: These molecules could be employed for combinatorial chemoprevention and interception approaches or chemoprevention/therapy regimens for cancer and other chronic complex diseases.

Keywords:

Nutraceuticals, phytochemical drugs, cancer, repurposed drugs, CD, aberrant angiogenesis.

Affiliation:

Scientific and Technology Park, IRCCS MultiMedica, Milano, Scientific and Technology Park, IRCCS MultiMedica, Milano, Scientific and Technology Park, IRCCS MultiMedica, Milano, Laboratory of Translational Research, IRCCS Arcispedale Santa Maria Nuova, Reggio Emilia, Scientific and Technology Park, IRCCS MultiMedica, Milano, Scientific and Technology Park, IRCCS MultiMedica, Milano, Scientific and Technology Park, IRCCS MultiMedica, Milano, Scientific and Technology Park, IRCCS MultiMedica, Milano



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