Barbara Budzynska, Caterina Faggio, Marta Kruk-Slomka, Dunja Samec, Seyed Fazel Nabavi, Antoni Sureda, Kasi Pandima Devi and Seyed Mohammad Nabavi* Pages 5152 - 5164 ( 13 )
Flavonoids are major dietary constituents of plant-based food found ubiquitously in plant kingdom where they are usually present in substantial amounts. Rutin is a flavonol-type polyphenol which consists of the flavonol quercetin and the disaccharide rutinose. Rutin has been reported to exert diverse biological effects such as antitumor and antimicrobial mainly associated to its antioxidant and anti-inflammatory activities. Mental, neurological, and behavioural disorders are an important and growing cause of morbidity. Most of these disorders combine a high prevalence, early onset, progressive clinical course, and impairment of critical brain functions making them a major contributor to the global disease burden. In the present work, the biological in vitro and in vivo effects and the potential therapeutic applications of rutin in neurodegenerative processes are reviewed, as well as their bioavailability and pharmacokinetics, which are essential for a better understanding of its biological effectiveness. Moreover, the present review also provides an overview of the molecular mechanisms through which rutin is proposed to exert its neuroprotective effects.
Alzheimer's disease, antioxidant, flavonoid, neurodegenerative diseases, polyphenols, rutin.
Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4a Street, 20- 093 Lublin, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina Viale Ferdinando Stagno d'Alcontres, 31 98166, S.Agata, Messina, Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodzki 4a Street, 20- 093 Lublin, Department of Molecular Biology, Institute Ruder Boskovic, Bijenicka c. 54, 10000 Zagreb, Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Research Group on Community Nutrition and Oxidative Stress (NUCOX), University of Balearic Islands, E-07122 Palma de Mallorca, Balearic Islands, Department of Biotechnology, Alagappa University, Karaikudi 630 004, Tamil Nadu, Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran