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The Significance of Oxidized Low-Density Lipoprotein in Body Fluids as a Marker Related to Diseased Conditions

Author(s):

Hiroyuki Itabe*, Rina Kato, Naoko Sasabe, Takashi Obama and Matsuo Yamamoto   Pages 1 - 18 ( 18 )

Abstract:


Oxidatively modified low-density lipoprotein (oxLDL) is known to be involved in various diseases, including cardiovascular diseases. The presence of oxLDL in the human circulatory system and in atherosclerotic lesions has been demonstrated using monoclonal antibodies. Studies have shown the significance of circulating oxLDL in various systemic diseases, including acute myocardial infarction and diabetic mellitus. Several different enzyme-linked immunosorbent assay (ELISA) procedures to measure oxLDL were utilized. Evidence has been accumulating that reveals changes in oxLDL levels under certain pathological conditions. Since oxLDL concentration tends to correlate with lowdensity lipoprotein (LDL)-cholesterol, the ratio of ox-LDL and LDL rather than oxLDL concentration alone has also been focused. In addition to circulating plasma, LDL and oxLDL are found in gingival crevicular fluid (GCF), where the ratio of oxLDL to LDL in GCF is much higher than in plasma. LDL and oxLDL levels in GCF show an increase in diabetic patients and periodontal patients, suggesting that GCF might be useful in examining systemic conditions. GCF oxLDL increased when the teeth were affected by periodontitis. It is likely that oxLDL levels in plasma and GCF could reflect oxidative stress and transfer efficacy in the circulatory system.

Keywords:

lipoproteins, oxLDL, oxLDL/LDL ratio, oxidized phosphatidylcholine, AMI, periodontitis, GCF, transcytosis.

Affiliation:

Division of Biological Chemistry, Department of Molecular Biology, Showa University School of Pharmacy, Tokyo, Division of Biological Chemistry, Department of Molecular Biology, Showa University School of Pharmacy, Tokyo, Division of Biological Chemistry, Department of Molecular Biology, Showa University School of Pharmacy, Tokyo, Division of Biological Chemistry, Department of Molecular Biology, Showa University School of Pharmacy, Tokyo, Department of Periodontology, Showa University School of Dentistry, Tokyo



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