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Flavonols and Flavones – Protecting Against Myocardial Ischemia/ Reperfusion Injury by Targeting Protein Kinases

Author(s):

Owen L. Woodman*, Kai Yee Chin, Colleen J. Thomas, Dominic C.H. Ng and Clive N. May   Pages 1 - 14 ( 14 )

Abstract:


In acute myocardial infarction (AMI), the first line of treatment is to rapidly restore blood flow to the ischemic myocardium to limit infarct size. It is now well established that though clearly beneficial, the positive outcomes of this intervention are limited by injury in response to the reperfusion itself in addition to the prior ischemia. This process is described as reperfusion injury and is considered to contribute to the arrhythmias, microvascular dysfunction and impaired cardiac contractility that is observed even after the restoration of coronary blood flow. Thus an important, currently unmet, therapeutic challenge is to address the outcomes of this reperfusion injury. In this article, we review the evidence that flavonols and flavones may prove useful in preserving cardiac function after ischemia and reperfusion and consider the possible mechanisms, in particular, the inhibition of kinases, by which they may exert protection.

Keywords:

Antioxidant, cardioprotection, ischemia-reperfusion, reactive oxygen species, flavone, flavonol, kinase

Affiliation:

School of Health & Biomedical Sciences, RMIT University, Bundoora, Victoria, School of Health & Biomedical Sciences, RMIT University, Bundoora, Victoria, Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Bundoora, Victoria, School of Biomedical Science, University of Queensland. St Lucia, Queensland, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria



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