Elena Aguilera, Guzman Alvarez, Hugo Cerecetto and Mercedes Gonzalez *
The current treatment of Chagas disease is based on monopharmacology where the used drugs have limited efficacy and severe side effects. In order to overcome these limitations some tools have been described including development or isolation of new drugs, drug repositioning, and polypharmacology. Here we review the polypharmacology strategy where compounds belonging to different structural chemotypes were combined in order to affect different biochemical pathways of T. cruzi parasite. Therefore ergosterol biosynthesis inhibitors, anti-inflammatory agents, cardiac dysfunction drugs, trypanothione reductase inhibitors, vitamins, between others, were combined looking for new anti-Chagas treatment. Natural products were also used in the application of this strategy.
Chagas disease, polypharmacology, synergism, antagonism, isobologram
Grupo de Quimica Medicinal, Facultad de Ciencias, Universidad de la República Montevideo, Grupo de Quimica Medicinal, Facultad de Ciencias, Universidad de la República, Montevideo, Grupo de Quimica Medicinal, Facultad de Ciencias, Universidad de la Republica, Montevideo, Laboratorio de Moleculas Bioactivas, Centro Universitario Regional Litoral Norte, Universidad de la Republica Paysandu