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Advances and Application of DNA-functionalized Nanoparticles

[ Vol. 26 , Issue. 40 ]

Author(s):

Xun Zhang , Fei Wang, Jin-Liang Sheng* and Min-Xuan Sun*   Pages 7147 - 7165 ( 19 )

Abstract:


DNA-functionalized nanoparticle (DfNP) technology, the integration of DNA with nanotechnology, has emerged over recent decades as a promising biofunctionalization tool in the light of biotechnological approaches. The development of DfNPs has exhibited significant potential for several biological and biomedical applications. In this review, we focus on the mechanism of a series of DNA-NP nanocomposites and highlight the superstructures of DNA-based NPs. We also summarize the applications of these nanocomposites in cell imaging, cancer therapy and bioanalytical detection.

Keywords:

DNA, nanoparticle, cancer therapy and imaging, bioanalysis, biofunctionalization, biomedical applications.

Affiliation:

Jiangsu Key Laboratory of Medical Optics, Chinese Academy of Sciences, Suzhou, Shanghai Tuberculosis Key Laboratory, Shanghai Pulmonary Hospital, Tongji University, Shanghai, College of Animal Science and Technology, Shihezi University, Shihezi, Jiangsu Key Laboratory of Medical Optics, Chinese Academy of Sciences, Suzhou



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