Maria Assunta Chiacchio , Daniela Iannazzo , Roberto Romeo, Salvatore V. Giofrè and Laura Legnani* Pages 7166 - 7195 ( 30 )
Pyridine and pyrimidine derivatives have received great interest in recent pharmacological research, being effective in the treatment of various malignancies, such as myeloid leukemia, breast cancer and idiopathic pulmonary fibrosis. Most of the FDA approved drugs show a pyridine or pyrimidine core bearing different substituents. The aim of this review is to describe the most recent reports in this field, with reference to the newly discovered pyridineor pyrimidine-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding benzo-fused heterocyclic compounds, i.e. quinolines and quinazolines, are also reported.
Nitrogenated heterocycles, pyridine, pyrimidine, biological activities, synthesis, molecular modeling.
Dipartimento di Scienze del Farmaco, University of Catania, V.le Doria 6, 95125 Catania, Dipartimento di Ingegneria, University of Messina, Contrada Di Dio, 98166 Messina, Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, University of Messina, Via S.S. Annunziata, 98168 Messina, Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, University of Messina, Via S.S. Annunziata, 98168 Messina, Dipartimento di Chimica, University of Pavia, Via Taramelli 12, 27100 Pavia