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Use of Anticancer Platinum Compounds in Combination Therapies and Challenges in Drug Delivery

Author(s):

Xiao Xiao, James Trevor Oswald, Ting Wang, Weina Zhang and Wenliang Li*   Pages 1 - 21 ( 21 )

Abstract:


As one of the leading and most important metal-based drugs, platinum-based pharmaceuticals are widely used in the treatment of solid malignancies. Despite significant side effects and acquired drug resistance have limited their clinical applications, platinum has shown strong inhibitory effects for a wide assortment of tumors. Drug delivery systems using emerging technologies such as liposomes, dendrimers, polymers, nanotubes and other nanocompositions, all show promise for the safe delivery of platinum-based compounds. Due to the specificity of nano-formulations; unwanted side-effects and drug resistance can be largely averted. In addition, combinational therapy has been shown to be an effective way to improve the efficacy of platinum based anti-tumor drugs. This review first introduces drug delivery systems used for platinum and combinational therapeutic delivery. Then we highlight some of the recent advances in the field of drug delivery for combinational therapy; specifically progress in leveraging the cytotoxic nature of platinum-based drugs, the combinational effect of other drugs with platinum, while evaluating the drug targeting, side effect reducing and sitespecific nature of nanotechnology-based delivery platforms.

Keywords:

Drug delivery, drug combination, platinum drug, nanoparticle.

Affiliation:

School of Pharmacy, Jilin Medical University, Jilin, 132013, School of Nanotechnology Engineering, University Of Waterloo, Waterloo, Department of the Gastrointestinal Surgery, The first Hospital of Jilin University, Changchun, Jilin 130021, Common Subjects Department, Shangqiu Medical College, Henan 476100, School of Pharmacy, Jilin Medical University, Jilin, 132013



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