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Discovery of Dengue Virus Inhibitors

Author(s):

Adib Afandi Abdullah, Yean Kee Lee, Sek Peng Chin, See Khai Lim, Vannajan Lee, Rozana Othman, Shatrah Othman, Noorsaadah Abdul Rahman, Rohana Yusof and Choon Han Heh*   Pages 1 - 91 ( 91 )

Abstract:


To date, there is still no approved anti-dengue agent to treat dengue infection in the market. Although the only licensed dengue vaccine, Dengvaxia is available, its protective efficacy against serotypes 1 and 2 of dengue virus was reported to be lower than serotypes 3 and 4. Moreover, according to WHO, the risk of being hospitalized and having severe dengue increased in seronegative individuals after they received Dengvaxia vaccination. Nevertheless, various studies had been carried out in search of dengue virus inhibitors. These studies focused on the structural (C, prM, E) and non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) of dengue virus as well as host factors as drug targets. Hence, this article provides an overall up-to-date review of the discovery of dengue virus inhibitors that are only targeting the structural and non-structural viral proteins as drug targets.

Keywords:

Drug discovery, dengue virus, virus inhibitors, structural proteins, non-structural proteins, drug targets

Affiliation:

Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur



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