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Metabolism of Rhaponticin and Activities of its Metabolite, Rhapontigenin: A Review

Author(s):

Dan Chen , Jing-Ru Liu, Yanjin Cheng, Hua Cheng, Ping He and Yang Sun*   Pages 1 - 17 ( 17 )

Abstract:


Rhaponticin is a stilbenoid glucoside compound, can be found in medicinal plant of rhubarb rhizomes. Rhapontigenin (RHAG), the stilbene aglycone metabolite of rhaponticin, has shown various biological activities including anticancer activities to act a potential human cytochrome P450 inhibitor, antihyperlipidemic effect, anti-allergic action, antioxidant and antibacterial activities. Moreover, it was reported to scavenge intravellular reactive oxygen species (ROS), the 1,1-diphenyl-2-picrylliydrazyl (DPPH) radical, and hydrogen peroxide (H2O2). Meanwhile, RHAG exhibited the inhibitory activity for synthesis of DNA, RNA and protein, and also presented the capacity of inducing morphological changes and apoptosis of C. albicans. Here, the structure, pharmacokinetics, pharmacological effects as well as underlying mechanisms of rhaponticin and its metabolite, RHAG, have been extensively reviewed. This review will provide a certain reference value for developing the therapeutic drug of rhaponticin or RHAG.

Keywords:

Metabolism, Pharmacokinetics, Cardiovascular disease, Cancer, Rhaponticin, Rhapontigenin

Affiliation:

School of Food Science and Technology, School of Chemical Engineering, Hubei University of Arts and Science, Xiangyang, Hubei 441053, School of Life Science, Northwest University, Xi’an, Shaanxi 710069, School of Mathematics and Statistics, Hubei University of Arts and Science, Xiangyang, Hubei 441053, School of Food Science and Technology, School of Chemical Engineering, Hubei University of Arts and Science, Xiangyang, Hubei 441053, School of Food Science and Technology, School of Chemical Engineering, Hubei University of Arts and Science, Xiangyang, Hubei 441053, School of Food Science and Technology, School of Chemical Engineering, Hubei University of Arts and Science, Xiangyang, Hubei 441053



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