Fan Jiang, Yunqi Zhu, Changyang Gong* and Xin Wei* Pages 1 - 20 ( 20 )
Atherosclerosis is the leading inducement of cardiovascular diseases, which ranks the first cause of the global deaths. It is an arterial disease associated with dyslipidemia and changes in the composition of the vascular wall. Besides invasive surgical strategy, the current conservative clinical treatment for atherosclerosis falls into two categories, lipid regulating-based therapy and anti-inflammatory therapy. However, the existing strategies based on conventional drug delivery systems have shown limited efficacy against disease development and plenty of side effects. Nanomedicine has great potential in the development of targeted therapy, controlled drug delivery and release, the design of novel specific drugs and diagnostic modalities, and biocompatible scaffolds with multifunctional characteristics, which has led to an evolution in the diagnosis and treatment of atherosclerosis. This paper will focus on the latest nanomedicine strategies for atherosclerosis diagnosis and treatment as well as discussing about the potential therapeutic targets during atherosclerosis progress, which could form the basis of development of novel nanoplatform against atherosclerosis.
atherosclerosis, cardiovascular diseases, nanomedicine, drug delivery system, diagnosis, treatment, theranostics, scaffolds
School of Medicine, University of Electronic Science and Technology of China, Chengdu , School of Medicine, University of Electronic Science and Technology of China, Chengdu , State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy , Chengdu , School of Medicine, University of Electronic Science and Technology of China, Chengdu