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99mTc-Radiolabelled Peptides for Tumour Imaging: Present and Future

[ Vol. 17 , Issue. 24 ]


C. Bolzati, F. Refosco, A. Marchiani and P. Ruzza   Pages 2656 - 2683 ( 28 )


Receptor-binding peptides have attracted an enormous interest in targeting molecules for the development of tumour specific radiopharmaceutical compounds. The overexpression of many receptors on human tumour makes such peptide-ligands attractive agents for diagnostic imaging and therapy of cancers. The use of solid-phase peptide synthesis and the availability of a wide range of bifunctional chelating agents for the radiolabelling of bioactive peptides with radionuclides have produced a wide variety of useful radiopharmaceutical molecules. For diagnostic purposes, techenetium- 99m is the ideal radionuclide thanks to its nuclear properties and the availability of a low cost portable generator system.


Peptide receptors,radiolabelled peptides,technetium,tumour imaging


, , , Institute of Biomolecular Chemistry of CNR, Padova Unit, via Marzolo 1, 35131 Padova, Italy.

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