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Factors Affecting the Metabolite Productions in Endophytes: Biotechnological Approaches for Production of Metabolites

[ Vol. 27 , Issue. 11 ]

Author(s):

Viridiana Morales-Sánchez, Maria Fe Andrés, Carmen Elisa Díaz and Azucena González-Coloma*   Pages 1855 - 1873 ( 19 )

Abstract:


Since 1980, many species and different strains from endophytic genera of Phomopsis, Fusarium, Pestaliopsis and Aspergillus have been studied because of their ability to produce medicinal compounds found in their host plants. Some of these medicinal agents such as Taxol, Brefeldine A, Camptothecin and Podophyllotoxin are being produced in large-scale after an optimization process. However, the potential of fungal endophytes to produce host-like medicinal compounds remains largely unexplored.

Keywords:

Endophytes, secondary metabolites, anticancer, drugs, biotechnology, medicinal compounds.

Affiliation:

Instituto de Ciencias Agrarias, CSIC, Serrano 115-dpdo, Madrid 28006, Instituto de Ciencias Agrarias, CSIC, Serrano 115-dpdo, Madrid 28006, Instituto de Productos naturales y Agrobiologia, CSIC. Avda. Astrofísico F. Sanchez, 3. 38206 La Laguna, Tenertife, Instituto de Ciencias Agrarias, CSIC, Serrano 115-dpdo, Madrid 28006



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