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Immune-Based Therapies for Traumatic Brain Injury: Insights from Pre-Clinical Studies

Author(s):

Caroline Amaral Machado, Ana Cristina Simões e Silva*, Amanda Silva de Miranda, Thiago Macedo e Cordeiro, Rodrigo Novaes Ferreira, Leonardo Cruz de Souza, Antônio Lúcio Teixeira and Aline Silva de Miranda   Pages 1 - 28 ( 28 )

Abstract:


Traumatic brain injury (TBI) is a major public health problem. It is the leading cause of death and disability, especially among children and young adults. The neurobiology basis underlying TBI pathophysiology remains to be fully revealed. Over the past years, emerging evidence has supported the hypothesis that TBI is an inflammatory based condition, paving the way for the development of potential therapeutic targets. There is no treatment capable to prevent or minimize TBI-associated outcomes. Therefore, the search for effective therapies is a priority goal. In this context, animal models have become valuable tools to study molecular and cellular mechanisms involved in TBI pathogenesis as well as novel treatments. Herein, we discuss therapeutic strategies to treat TBI focused on immunomodulatory and/or anti-inflammatory approaches in the pre-clinical setting.

Keywords:

Traumatic Brain Injury; , Inflammation; , Treatment; , Immunomodulatory Agents

Affiliation:

Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, UFMG, Laboratório Interdisciplinar de Investigação Médica (LIIM), Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil. 3Departamento de Pediatria, Faculdade de Medicina, UFMG, Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Laboratório Interdisciplinar de Investigação Médica (LIIM), Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil. 3Departamento de Pediatria, Faculdade de Medicina, UFMG, Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, UFMG, Laboratório Interdisciplinar de Investigação Médica (LIIM), Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Brazil. 3Departamento de Pediatria, Faculdade de Medicina, UFMG, Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Laboratório de Neurobiologia, Departamento de Morfologia, Instituto de Ciências Biológicas, UFMG



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