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Pharmacological Advances in the Treatment of Age-related Macular Degeneration

[ Vol. 27 , Issue. 4 ]

Author(s):

María Gil-Martínez, Paz Santos-Ramos, Maribel Fernández-Rodríguez , Maximino J. Abraldes, Maria José Rodríguez-Cid, María Santiago-Varela, Anxo Fernández-Ferreiro* and Francisco Gómez-Ulla *   Pages 583 - 598 ( 16 )

Abstract:


Age-related macular degeneration is an acquired degenerative disease that is responsible for severe loss of vision in elderly people. There are two types: dry age-related macular degeneration and wet age-related macular degeneration. Its treatment has been improved and tries to be tailored in the future. The aim of this review is to summarize the pharmacological advances in the treatment of age-related macular degeneration. Regarding dry AMD, there is no effective treatment to reduce its progression. However, some molecules such as lampalizumab and eculizumab were under investigation, although they have shown low efficacy. Herein, in an attempt to prevent dry AMD progression, the most important studies suggested increasing the antioxidants intake and quitting the smoke habit. On the other hand, wet AMD has more developed treatment. Nowadays, the gold standard treatment is anti-VEGF injections. However, more effective molecules are currently under investigation. There are different molecules under research for dry AMD and wet AMD. This fact could help us treat our patients with more effective and lasting drugs but more clinical trials and safety studies are required in order to achieve an optimal treatment.

Keywords:

Age-related macular degeneration, choroidal neovascularization, pharmacology, vascular endothelial growth factor, molecules, treatment.

Affiliation:

Department of Ophthalmology, Hospital Universitario Santiago de Compostela, Santiago de Compostela, Department of Ophthalmology, Hospital Universitario Santiago de Compostela, Santiago de Compostela, Department of Ophthalmology, Hospital Universitario Santiago de Compostela, Santiago de Compostela, Department of Ophthalmology, Hospital Universitario Santiago de Compostela, Santiago de Compostela, Department of Ophthalmology, Hospital Universitario Santiago de Compostela, Santiago de Compostela, Department of Ophthalmology, Hospital Universitario Santiago de Compostela, Santiago de Compostela, Pharmacy Department and Pharmacology Group, Univ Hospital of Santiago de Compostela (SERGAS) and Health Research Intitute (IDIS), Santiago de Compostela, Instituto Oftalmologico Gomez-Ulla, Santiago de Compostela



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